- 靶点:
- ZFP91
- 基因名称:
- ZFP91 ZNF757 FKSG11
- 蛋白名称:
- zinc finger protein 91 homolog (mouse); ZFP91-CNTF readthrough transcript; ciliary neurotrophic factor
- Human Gene Id:
- 80829
- Human Swiss Prot No:
- Q96JP5
- Mouse Gene Id:
- 109910
- Mouse Swiss Prot No:
- Q62511
- 免疫原:
- The antiserum was produced against synthesized peptide derived from the Internal region of human ZFP91. AA range:401-450
- 特异性:
- The antibody detects endogenous ZFP91 protein
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500-2000, ELISA 1:10000-20000
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度:
- 1 mg/ml
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- ZFP91 ZNF757 FKSG11
- 实测条带:
- 60kD
- 背景:
- The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010],
- 功能:
- disease:Overexpressed in most acute myelogenous leukemia (AML) cases (27 over 29).,function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.,function:May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis.,online information:Ciliary neurotrophic factor entry,similarity:Belongs to the CNTF family.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Homodimer.,tissue specificity:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.,tissue specificity:Nervous system.,
- 细胞定位:
- Nucleus .
- 组织表达:
- Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.
Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy
货号:YT5823
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of hepg2, NT28 cells using Antibody diluted at 500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000