• 靶点：
• UCP2

• 基因名称：
• UCP2

• 蛋白名称：
• Mitochondrial uncoupling protein 2

• Human Gene Id：
• 7351

• Human Swiss Prot No：
• P55851

• Mouse Gene Id：
• 22228

• Mouse Swiss Prot No：
• P70406

• Rat Gene Id：
• 54315

• Rat Swiss Prot No：
• P56500

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human UCP2. AA range:64-113

• 特异性：
• UCP2 Polyclonal Antibody detects endogenous levels of UCP2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• UCP2;SLC25A8;Mitochondrial uncoupling protein 2;UCP 2;Solute carrier family 25 member 8;UCPH

• 分子量：
• 33kD

• 背景：
• Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [prov

• 功能：
• function:UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.,polymorphism:Genetic variation in UCP2 influences susceptibility to obesity [MIM:607447]; also called body mass index quantitative trait locus type 4 (BMIQ4). Obesity is the most common nutritional disorder in Western society.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Acts as a dimer forming a proton channel.,tissue specificity:Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.,

• 细胞定位：
• Mitochondrion inner membrane; Multi-pass membrane protein.

• 组织表达：
• Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Identification and Verification of Hub Mitochondrial Dysfunction Genes in Osteoarthritis Based on Bioinformatics Analysis Journal of Immunology Research Hui Niu WB Human 1:1000 Chondrocytes
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