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TBX3 Polyclonal Antibody

货号：YT4571
应用：WB;ELISA
种属：Human;Mouse;Rat

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靶点：
TBX3

简介：
>>Signaling pathways regulating pluripotency of stem cells

基因名称：
TBX3

蛋白名称：
T-box transcription factor TBX3

Human Gene Id：
6926

Human Swiss Prot No：
O15119

Mouse Gene Id：
21386

Mouse Swiss Prot No：
P70324

Rat Gene Id：
353305

Rat Swiss Prot No：
Q7TST9

免疫原：
The antiserum was produced against synthesized peptide derived from human TBX3. AA range:301-350

特异性：
TBX3 Polyclonal Antibody detects endogenous levels of TBX3 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
TBX3;T-box transcription factor TBX3;T-box protein 3

实测条带：
79kD

背景：
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],

功能：
disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed.,

细胞定位：
Nucleus .

组织表达：
Widely expressed.

The method of sinus node-like pacemaker cells from human induced pluripotent stem cells by BMP and Wnt signaling CELL BIOLOGY AND TOXICOLOGY Huang, Congxin WB Human human induced pluripotent stem cells (hiPSCs)
货号：YT4571