PDGF-A Polyclonal Antibody

    • 货号:YT3630
    • 应用:WB;IHC;IF;ELISA
    • 种属:Human;Mouse;Rat
      • 靶点:
      • PDGF-A
      • 简介:
      • >>EGFR tyrosine kinase inhibitor resistance;>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>Phospholipase D signaling pathway;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>Gap junction;>>JAK-STAT signaling pathway;>>Regulation of actin cytoskeleton;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>MicroRNAs in cancer;>>Glioma;>>Prostate cancer;>>Melanoma;>>Choline metabolism in cancer;>>Fluid shear stress and atherosclerosis
      • 基因名称:
      • PDGFA
      • 蛋白名称:
      • Platelet-derived growth factor subunit A
      • Human Gene Id:
      • 5154
      • Human Swiss Prot No:
      • P04085
      • Mouse Swiss Prot No:
      • P20033
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human PDGF-A. AA range:105-154
      • 特异性:
      • PDGF-A Polyclonal Antibody detects endogenous levels of PDGF-A protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • PDGFA;PDGF1;Platelet-derived growth factor subunit A;PDGF subunit A;PDGF-1;Platelet-derived growth factor A chain;Platelet-derived growth factor alpha polypeptide
      • 实测条带:
      • 17kD
      • 背景:
      • platelet derived growth factor subunit A(PDGFA) Homo sapiens This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
      • 功能:
      • domain:The long form contains a basic insert which acts as a cell retention signal.,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.,
      • 细胞定位:
      • Secreted. Released by platelets upon wounding.
      • 组织表达:
      • PCR rescued clones,

      Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2019 Apr;112:108669 WB Mouse Primary murine lung fibroblasts (PMLFs)
      货号:YT3630

      • 产品图片
      • Western Blot analysis of various cells using PDGF-A Polyclonal Antibody
      • Immunohistochemistry analysis of PDGF-A antibody in paraffin-embedded human lung carcinoma tissue.
      • Western blot analysis of lysate from Jurkat cells, using PDGF-A antibody.