• 靶点：
• C/EBP α

• 简介：
• >>Non-alcoholic fatty liver disease;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia

• 基因名称：
• CEBPA

• 蛋白名称：
• CCAAT/enhancer-binding protein alpha

• Human Gene Id：
• 1050

• Human Swiss Prot No：
• P49715

• Mouse Gene Id：
• 12606

• Mouse Swiss Prot No：
• P53566

• Rat Gene Id：
• 24252

• Rat Swiss Prot No：
• P05554

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human C/EBP-alpha. AA range:6-55

• 特异性：
• C/EBP α Polyclonal Antibody detects endogenous levels of C/EBP α protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CEBPA;CCAAT/enhancer-binding protein alpha;C/EBP alpha

• 实测条带：
• 42kd

• 背景：
• This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],

• 功能：
• function:C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X.,

• 细胞定位：
• Nucleus .; [Isoform 4]: Nucleus, nucleolus .

• 组织表达：
• Liver,Pancreas,Umbilical cord,White Matter pool- 5 brain tissues- f

Long noncoding RNA CEBPA-DT promotes cisplatin chemo-resistance through CEBPA/BCL2 mediated apoptosis in oral squamous cellular cancer. International Journal of Medical Sciences Int J Med Sci. 2021; 18(16): 3728–3737 WB Human 1:500 Cal27-CisR,HSC4-CisR
货号：YT0551

Long non-coding RNA CEBPA-AS1 correlates with poor prognosis and promotes tumorigenesis via CEBPA/Bcl2 in oral squamous cell carcinoma. CANCER BIOLOGY & THERAPY 2018 Jan 15 WB Human 1:500 Tca8113 cell,Cal27 cell
货号：YT0551

魏孔熙, et al. "黄芪多糖对 X 线辐射骨髓间充质干细胞成脂分化的影响." Journal of Xi'an Jiaotong University (Medical Sciences) 41.2 (2020).
货号：YT0551

Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE‐PDT in MG63 cells. Cancer Medicine 2016 Oct 03 WB Human MG63 cell
货号：YT0551

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