TBK1/NAK (Phospho Ser172) rabbit pAb

  • 货号：YP1527
  • 应用：ELISA
  • 种属：Human;Mouse
    • 靶点：
    • TBK1
    • 简介：
    • >>Ras signaling pathway;>>Mitophagy - animal;>>Autophagy - animal;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>IL-17 signaling pathway;>>Alcoholic liver disease;>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Yersinia infection;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>Coronavirus disease - COVID-19;>>Lipid and atherosclerosis
    • 基因名称：
    • TBK1 NAK
    • 蛋白名称：
    • TBK1/NAK (Ser172)
    • Human Swiss Prot No：
    • Q9UHD2
    • Mouse Swiss Prot No：
    • Q9WUN2
    • 免疫原：
    • Synthesized phosho peptide around human TBK1 and NAK (Ser172)
    • 特异性：
    • This antibody detects endogenous levels of Human Mouse TBK1/NAK (phospho-Ser172)
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • ELISA: 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
    • 实测条带：
    • 80kD
    • 背景：
    • The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010],
    • 功能：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immu
    • 细胞定位：
    • Cytoplasm . Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. .
    • 组织表达：
    • Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina.

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    相关报价

    • 货号：
    • YP1527
    • 规格：
    • 50μL / 100μL / 200μL
    • 价格：
    • 1500 / 2800 / 4680
    • 货期：
    • 预计发货时间为
      2024-05-10
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