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GAP43 Polyclonal Antibody

货号：YN5586
应用：WB
种属：Human;Mouse;Rat

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靶点：
GAP-43

基因名称：
GAP43

蛋白名称：
Neuromodulin

Human Gene Id：
2596

Human Swiss Prot No：
P17677

Mouse Gene Id：
14432

Mouse Swiss Prot No：
P06837

Rat Gene Id：
29423

Rat Swiss Prot No：
P07936

免疫原：
Recombinant Protein of Neuromodulin

特异性：
The antibody detects endogenous GAP43 protein.

组成：
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:1000-3000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
GAP43;Neuromodulin;Axonal membrane protein GAP-43;Growth-associated protein 43;Neural phosphoprotein B-50;pp46

实测条带：
38,43kD

背景：
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

功能：
function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,

细胞定位：
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .

组织表达：
Alzheimer cortex,Brain,Subthalamic nucleus,

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货号：YN5586