- 靶点：
- DKK2
- 简介：
- >>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases
- 基因名称：
- DKK2 UNQ682/PRO1316
- 蛋白名称：
- Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)
- Human Gene Id：
- 27123
- Human Swiss Prot No：
- Q9UBU2
- Mouse Swiss Prot No：
- Q9QYZ8
- 免疫原：
- Synthesized peptide derived from part region of human protein
- 特异性：
- DKK2 Polyclonal Antibody detects endogenous levels of protein.
- 组成：
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 实测条带：
- 28kD
- 背景：
- This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008],
- 功能：
- function:Inhibitor of Wnt signaling pathway .,PTM:May be proteolytically processed by a furin-like protease.,similarity:Belongs to the dickkopf family.,tissue specificity:Expressed in heart, brain, skeletal muscle and lung.,
- 细胞定位：
- Secreted.
- 组织表达：
- Expressed in heart, brain, skeletal muscle and lung.
Generation of a DKK2 homozygous knockout human embryonic stem cell line using the CRISPR/Cas9 system. Stem Cell Research Stem Cell Res. 2021 Dec;57:102611 ICC Human 1:300 hESCs
货号：YN2130
ARHGAP9 knockdown promotes lung adenocarcinoma metastasis by activating Wnt/β-catenin signaling pathway via suppressing DKK2. Wenzhou Zhang WB Human 1:1000 H1299 cell
货号：YN2130
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- Antibody-FAQs
- 产品图片
- Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night
