• 靶点：
• Collagen I

• 简介：
• >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Platelet activation;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Protein digestion and absorption;>>Amoebiasis;>>Human papillomavirus infection;>>Proteoglycans in cancer;>>Diabetic cardiomyopathy

• 基因名称：
• COL1A1

• 蛋白名称：
• Collagen alpha-1(I) chain (Alpha-1 type I collagen)

• Human Gene Id：
• 1277/1278

• Human Swiss Prot No：
• P08123/P02452

• Mouse Swiss Prot No：
• P11087

• Rat Swiss Prot No：
• P02454

• 免疫原：
• Synthetic Peptide of Collagen I

• 特异性：
• The antibody detects endogenous Collagen I protein

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• IF 1:50-200. IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Collagen alpha-1(I) chain (Alpha-1 type I collagen)

• 实测条带：
• 139kD

• 背景：
• This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],

• 功能：
• disease:A chromosomal aberration involving COL1A1 is a cause of dermatofibrosarcoma protuberans (DFSP) [MIM:607907]. Translocation t(17;22)(q22;q13) with PDGF. DFSP is an uncommon, locally aggressive, but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It typically occurs during early or middle adult life and is most frequently located on the trunk and proximal extremities.,disease:Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.,disease:Defects in COL1A1 are a cause of osteogenesis imperfecta type I (OI-I) [MIM:166200]. OI-I is a dominantly inherited serious newborn disease character

• 细胞定位：
• Secreted, extracellular space, extracellular matrix .

• 组织表达：
• Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Clinical significance of COL1A1 and COL1A2 expression levels in hypopharyngeal squamous cell carcinoma. Oncology Letters Oncol Lett. 2020 Jul;20(1):803-809 IHC Human 1:200 Hypopharyngeal squamous cell carcinoma (HPSCC) tissue
货号：YM3764

Geometric constraint-triggered collagen expression mediates bacterial-host adhesion Nature Communications Feng Yuting IF Rat 1:50 IEC-6 cell
货号：YM3764

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