• 靶点：
• GFAP

• 简介：
• >>JAK-STAT signaling pathway

• 基因名称：
• GFAP

• 蛋白名称：
• Glial fibrillary acidic protein

• Human Gene Id：
• 2670

• Human Swiss Prot No：
• P14136

• Mouse Gene Id：
• 14580

• Mouse Swiss Prot No：
• P03995

• Rat Gene Id：
• 24387

• Rat Swiss Prot No：
• P47819

• 免疫原：
• Synthetic Peptide of GFAP

• 特异性：
• The antibody detects endogenous GFAP proteins.

• 组成：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:2000-5000 IF 1:200 IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GFAP;Glial fibrillary acidic protein;GFAP

• 实测条带：
• 45kD

• 背景：
• This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],

• 功能：
• alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-spe

• 细胞定位：
• Cytoplasm . Associated with intermediate filaments. .

• 组织表达：
• Expressed in cells lacking fibronectin.

Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn. Chinese Journal of Integrative Medicine Chin J Integr Med. 2021 Dec;27(12):912-918 WB Rat 1:1000 Lumbar spinal cord
货号：YM3059

Effects of altitude changes on mild‑to‑moderate closed‑head injury in rats following acute high‑altitude exposure. Experimental and Therapeutic Medicine 2018 Nov 27 IHC Rat Brain tissues
货号：YM3059

平昊达, et al. "慢性脑低灌注大鼠焦虑样行为与海马区域炎性细胞因子水平的相关性分析." 收藏 3 (2020).
货号：YM3059

The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation: Molecular Pain Jin Zheng WB Rat
货号：YM3059

Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro Oxidative Medicine and Cellular Longevity Lei Wang IHC, IF, WB Mouse, Rat
货号：YM3059

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