Beclin 1 mouse mAb

    • 货号:YM1326
    • 应用:WB;IP
    • 种属:Human;Mouse;Rat;Monkey;Hamster
      • 靶点:
      • Beclin 1
      • 简介:
      • >>Autophagy - other;>>Mitophagy - animal;>>Autophagy - animal;>>Apoptosis - multiple species;>>Apelin signaling pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Kaposi sarcoma-associated herpesvirus infection
      • 基因名称:
      • becn1
      • Human Gene Id:
      • 8678
      • Human Swiss Prot No:
      • Q14457
      • Mouse Swiss Prot No:
      • O88597
      • 免疫原:
      • Purified recombinant human Beclin 1 protein fragments expressed in E.coli.
      • 特异性:
      • This antibody detects endogenous levels of Beclin 1 and does not cross-react with related proteins.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Monoclonal, Mouse
      • 稀释:
      • wb 1:1000 IP:1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • APG6;ATG 6;ATG6;ATG6 autophagy related 6 homolog;Bcl-2-interacting protein beclin;Beclin 1 (coiled coil moesin like BCL2 interacting protein);Beclin 1 autophagy related;Beclin-1;Beclin1;BECN 1;BECN1;BECN1_HUMAN;Coiled coil myosin like BCL2 interacting protein;Coiled-coil myosin-like BCL2-interacting protein;GT197;Protein GT197;VPS 30;VPS30.
      • 实测条带:
      • 55kD
      • 背景:
      • beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
      • 功能:
      • function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,
      • 细胞定位:
      • Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .
      • 组织表达:
      • Ubiquitous.

      SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation. Cell Death & Disease Cell Death Dis. 2021 Feb;12(2):1-13 IP,WB Mouse,Human Kidney HK-2 cell
      货号:YM1326

      Shi, Yanan, et al. "Compound Danshen dripping pills prevented leptin deficiency-induced hepatic ER stress, stimulated autophagy, and improved insulin resistance of ob/ob mice." Evidence-Based Complementary and Alternative Medicine 2020 (2020).
      货号:YM1326

      • 产品图片
      • Deng, Z., Sun, M., Wu, J. et al. SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation. Cell Death Dis 12, 217 (2021). 
      • Deng, Z., Sun, M., Wu, J. et al. SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation. Cell Death Dis 12, 217 (2021). 
      • Western blot detection of Beclin 1 in Hela,3T3,C6,COS7,CHO-K1,Rat brain and Jurkat cell lysates using Beclin 1 mouse mAb (1:1000 diluted).Predicted band size:52KDa.Observed band size:55KDa.