• 靶点：
• LSD1

• 简介：
• >>Thermogenesis

• 基因名称：
• KDM1A

• 蛋白名称：
• Lysine-specific histone demethylase 1A

• Human Gene Id：
• 23028

• Human Swiss Prot No：
• O60341

• Mouse Gene Id：
• 99982

• Mouse Swiss Prot No：
• Q6ZQ88

• 免疫原：
• Purified recombinant human LSD1 (N-terminus) protein fragments expressed in E.coli.

• 特异性：
• LSD1 Monoclonal Antibody detects endogenous levels of LSD1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:1000 - 1:2000. IHC 1:500 - 1:1000. IF 1:100 - 1:500. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• KDM1A;AOF2;KDM1;KIAA0601;LSD1;Lysine-specific histone demethylase 1A;BRAF35-HDAC complex protein BHC110;Flavin-containing amine oxidase domain-containing protein 2

• 分子量：
• 93kD

• 背景：
• This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],

• 功能：
• cofactor:FAD.,domain:The SWIRN domain may act as an anchor site for a histone tail.,function:Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. May also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediate

• 细胞定位：
• Nucleus .

• 组织表达：
• Ubiquitously expressed.

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ Science Advances Xu Li IP Human
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