• 靶点：
• N-cadherin

• 简介：
• >>Cell adhesion molecules;>>Arrhythmogenic right ventricular cardiomyopathy

• 基因名称：
• CDH2

• 蛋白名称：
• Cadherin-2

• Human Gene Id：
• 1000

• Human Swiss Prot No：
• P19022

• Mouse Gene Id：
• 12558

• Mouse Swiss Prot No：
• P15116

• Rat Gene Id：
• 83501

• Rat Swiss Prot No：
• Q9Z1Y3

• 免疫原：
• Purified recombinant fragment of human N-cadherin expressed in E. Coli.

• 特异性：
• N-cadherin Monoclonal Antibody detects endogenous levels of N-cadherin protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CDH2;CDHN;NCAD;Cadherin-2;CDw325;Neural cadherin;N-cadherin;CD antigen CD325

• 背景：
• This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015],

• 功能：
• function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein . Cell membrane, sarcolemma . Cell junction . Cell surface . Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. .

• 组织表达：
• Brain,Epithelium,Liver,

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