• 靶点：
• HMGB1

• 简介：
• >>Base excision repair;>>Autophagy - animal;>>Necroptosis;>>Neutrophil extracellular trap formation

• 基因名称：
• HMGB1 HMG1

• 蛋白名称：
• High mobility group protein B1 (High mobility group protein 1) (HMG-1)

• Human Gene Id：
• 3146

• Human Swiss Prot No：
• P09429

• Mouse Gene Id：
• 100862258

• Mouse Swiss Prot No：
• P63158

• Rat Gene Id：
• 25459

• Rat Swiss Prot No：
• P63159

• 免疫原：
• Synthesized peptide derived from human HMGB1 AA range: 100-200

• 特异性：
• This antibody detects endogenous levels of HMGB1 protein.

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 稀释：
• WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• 纯化工艺：
• Protein G

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• High mobility group protein B1 (High mobility group protein 1) (HMG-1)

• 分子量：
• 25kD

• 实测条带：
• 24kD

• 背景：
• high mobility group box 1(HMGB1) Homo sapiens This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015],

• 功能：
• function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,

• 细胞定位：
• 0

• 组织表达：
• Ubiquitous. Expressed in platelets (PubMed:11154118).

Doxorubicin-Loaded Platelet Decoys for Enhanced Chemoimmunotherapy Against Triple-Negative Breast Cancer in Mice Model. Yunfeng Fu WB Mouse 4T1 cell
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