Integrin αE Polyclonal Antibody
- 货号:YT6021
- 应用:WB;IHC;IF;ELISA
- 种属:Human;Rat;Mouse;
- 简介:
- >>Regulation of actin cytoskeleton
- 蛋白名称:
- Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]
- 免疫原:
- Synthetic peptide from human protein at AA range: 710-770
- 特异性:
- The antibody detects endogenous Integrin αE
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500-2000 IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Integrin alpha-E (HML-1 antigen;Integrin alpha-IEL;Mucosal lymphocyte 1 antigen;CD antigen CD103) [Cleaved into: Integrin alpha-E light chain;Integrin alpha-E heavy chain]
- 背景:
- integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],
- 功能:
- domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.,induction:Integrin alpha-E/beta-7 is induced by TGFB1.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 5 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.,tissue specificity:Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.,
- 细胞定位:
- Membrane; Single-pass type I membrane protein.
- 组织表达:
- Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
- Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
- Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
- Immunohistochemical analysis of paraffin-embedded Human-colon, antibody was diluted at 1:100