• 靶点：
• CD11b

• 简介：
• >>Rap1 signaling pathway;>>Phagosome;>>Cell adhesion molecules;>>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Hematopoietic cell lineage;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Pertussis;>>Legionellosis;>>Leishmaniasis;>>Amoebiasis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia

• 基因名称：
• ITGAM CD11B CR3A

• 蛋白名称：
• Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD

• Human Gene Id：
• 3684

• Human Swiss Prot No：
• P11215

• Mouse Swiss Prot No：
• P05555

• 免疫原：
• Synthetic peptide from human protein at AA range: 280-360

• 特异性：
• The antibody detects endogenous CD11b

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Integrin alpha-M (CD11 antigen-like family member B;CR-3 alpha chain;Cell surface glycoprotein MAC-1 subunit alpha;Leukocyte adhesion receptor MO1;Neutrophil adherence receptor;CD antigen CD11b)

• 背景：
• integrin subunit alpha M(ITGAM) Homo sapiens This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

• 功能：
• disease:Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

• 组织表达：
• Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).

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