• 靶点：
• GABA T-1

• 简介：
• >>Synaptic vesicle cycle;>>GABAergic synapse

• 基因名称：
• SLC6A1 GABATR GABT1 GAT1

• 蛋白名称：
• Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)

• Human Gene Id：
• 6529

• Human Swiss Prot No：
• P30531

• Mouse Gene Id：
• 232333

• Mouse Swiss Prot No：
• P31648

• Rat Swiss Prot No：
• P23978

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human SLC6A1. AA range:170-220

• 特异性：
• The antibody detects endogenous GABA T-1

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Sodium- and chloride-dependent GABA transporter 1 (GAT-1;Solute carrier family 6 member 1)

• 实测条带：
• 50kD

• 背景：
• The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009],

• 功能：
• domain:The PDZ domain-binding motif is involved in the interaction with MPP5.,function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons.,subunit:Interacts with MPP5.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse . Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). .

• 组织表达：
• Brain,

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