RSK3 Polyclonal Antibody

    • 货号:YT5839
    • 应用:WB,ELISA
    • 种属:Human,Mouse
      • 基因名称:
      • RPS6KA2 MAPKAPK1C RSK3
      • 蛋白名称:
      • ribosomal protein S6 kinase, 90kDa, polypeptide 2; hypothetical LOC100127984
      • Human Gene Id:
      • 6196
      • Human Swiss Prot No:
      • Q15349
      • Mouse Swiss Prot No:
      • Q9WUT3
      • 免疫原:
      • Synthetic peptide from human protein at AA range: 330-400
      • 特异性:
      • The antibody detects endogenous RSK3 protein
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Rabbit
      • 稀释:
      • WB 1:500-2000, ELISA 1:10000-20000
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -20°C/1 year
      • 其他名称:
      • RPS6KA2 MAPKAPK1C RSK3
      • 分子量:
      • 80630
      • 实测条带:
      • 80
      • 背景:
      • ribosomal protein S6 kinase A2(RPS6KA2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016],
      • 功能:
      • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,
      • 细胞定位:
      • nucleus,nucleoplasm,cytoplasm,spindle,cytosol,ribosome,nuclear membrane,
      • 组织表达:
      • Brain,Muscle,
      • 产品图片
      • Western Blot analysis of hepg2, NT28 cells using Antibody diluted at 500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Western blot analysis of lysates from 293 cells, using Rsk-3 antibody.