• 靶点：
• BMP-10

• 简介：
• >>Cytokine-cytokine receptor interaction

• 基因名称：
• BMP10

• 蛋白名称：
• BMP-10

• Human Gene Id：
• 27302

• Human Swiss Prot No：
• O95393

• Mouse Gene Id：
• 12154

• Mouse Swiss Prot No：
• Q9R229

• Rat Swiss Prot No：
• Q4AEG6

• 免疫原：
• Synthesized peptide derived from BMP-10 at AA range: 361-410

• 特异性：
• BMP-10 Polyclonal Antibody detects endogenous levels of BMP-10

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000, ELISA 1:10000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• bone morphogenetic protein 10

• 实测条带：
• 48kD

• 背景：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016],

• 功能：
• function:Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.,online information:Bone morphogenetic protein 10 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

• 细胞定位：
• Secreted .

• 组织表达：
• Detected in mammary epithelia (at protein level).

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