• 靶点：
• Ubiquitin

• 简介：
• >>Ubiquitin mediated proteolysis;>>Mitophagy - animal;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Kaposi sarcoma-associated herpesvirus infection

• 基因名称：
• UBA52/RPS27A/UBB/UBC

• 蛋白名称：
• Ubiquitin

• Human Gene Id：
• 7311

• Human Swiss Prot No：
• P0CG47/P0CG48/P62979/P62987

• Mouse Gene Id：
• 22187/22190/78294/22186

• Rat Gene Id：
• 192255/50522/100912032/64156

• Rat Swiss Prot No：
• P0CG51/Q63429/P62982/P62986

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Ubiquitin. AA range:40-89

• 特异性：
• Ub Polyclonal Antibody detects endogenous levels of Ub protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• UBB;Polyubiquitin-B;UBC;Polyubiquitin-C;RPS27A;UBA80;UBCEP1;Ubiquitin-40S ribosomal protein S27a;Ubiquitin carboxyl extension protein 80;UBA52;UBCEP2;Ubiquitin-60S ribosomal protein L40;CEP52;Ubiquitin A-52 residue ribosomal pr

• 分子量：
• 18kD

• 背景：
• This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq

• 功能：
• function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.,miscellaneous:This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of ubiquitin.,miscellaneous:Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a

• 细胞定位：
• [Ubiquitin]: Cytoplasm . Nucleus . Mitochondrion outer membrane ; Peripheral membrane protein .

• 组织表达：
• Brain,Epithelium,Fetal brain cortex,Liver,Lung,Lung adenocarcinoma,Lung cancer,Lymphocyte,P

The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice. Molecular Plant Mol Plant. 2021 Oct;14:1699 WB Rice Leaves, flowers
货号：YT4793

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death & Disease Cell Death Dis. 2018 Feb;9(3):1-12 WB,IP Human HEK293T cell
货号：YT4793

Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Scientific Reports Sci Rep-Uk. 2015 Dec;5(1):1-10 WB Mouse jejunum
货号：YT4793

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