• 靶点：
• MCT4

• 简介：
• >>Central carbon metabolism in cancer

• 基因名称：
• SLC16A3

• 蛋白名称：
• Monocarboxylate transporter 4

• Human Gene Id：
• 9123

• Human Swiss Prot No：
• O15427

• Mouse Gene Id：
• 80879

• Mouse Swiss Prot No：
• P57787

• Rat Gene Id：
• 80878

• Rat Swiss Prot No：
• O35910

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MOT4. AA range:233-282

• 特异性：
• MCT4 Polyclonal Antibody detects endogenous levels of MCT4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SLC16A3;MCT4;Monocarboxylate transporter 4;MCT 4;Solute carrier family 16 member 3

• 实测条带：
• 49kD

• 背景：
• Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008],

• 功能：
• function:Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.,similarity:Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.,tissue specificity:Highly expressed in skeletal muscle.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Highly expressed in skeletal muscle.

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