• 靶点：
• IκB-ε

• 简介：
• >>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Neurotrophin signaling pathway;>>Adipocytokine signaling pathway;>>Epstein-Barr virus infection;>>PD-L1 expression and PD-1 checkpoint pathway in cancer

• 基因名称：
• NFKBIE

• 蛋白名称：
• NF-kappa-B inhibitor epsilon

• Human Gene Id：
• 4794

• Human Swiss Prot No：
• O00221

• Mouse Gene Id：
• 18037

• Mouse Swiss Prot No：
• O54910

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IkappaB-epsilon. AA range:131-180

• 特异性：
• IκB-ε Polyclonal Antibody detects endogenous levels of IκB-ε protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NFKBIE;IKBE;NF-kappa-B inhibitor epsilon;NF-kappa-BIE;I-kappa-B-epsilon;IkB-E;IkB-epsilon;IkappaBepsilon

• 实测条带：
• 45kD

• 背景：
• The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011],

• 功能：
• function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.,PTM:Serine phosphorylated; followed by proteasome-dependent degradation.,similarity:Belongs to the NF-kappa-B inhibitor family.,similarity:Contains 6 ANK repeats.,subunit:Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.,tissue specificity:Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.

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