• 靶点：
• Hexim1

• 基因名称：
• HEXIM1

• 蛋白名称：
• Protein HEXIM1

• Human Gene Id：
• 10614

• Human Swiss Prot No：
• O94992

• Mouse Gene Id：
• 192231

• Mouse Swiss Prot No：
• Q8R409

• Rat Gene Id：
• 498008

• Rat Swiss Prot No：
• Q5M9G1

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230

• 特异性：
• Hexim1 Polyclonal Antibody detects endogenous levels of Hexim1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HEXIM1;CLP1;EDG1;HIS1;MAQ1;Protein HEXIM1;Cardiac lineage protein 1;Estrogen down-regulated gene 1 protein;Hexamethylene bis-acetamide-inducible protein 1;Menage a quatre protein 1

• 实测条带：
• 40kD

• 背景：
• Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.,miscellaneous:Inhibits Tat activity which is required for HIV-1 transcription.,similarity:Belongs to the HEXIM family.,subcellular location:Binds alpha-importin and is mostly nuclear.,subunit:Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, H

• 细胞定位：
• Nucleus . Cytoplasm . Binds alpha-importin and is mostly nuclear (PubMed:16362050).

• 组织表达：
• Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.

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