• 靶点：
• DHSO

• 简介：
• >>Pentose and glucuronate interconversions;>>Fructose and mannose metabolism;>>Metabolic pathways

• 基因名称：
• SORD

• 蛋白名称：
• DHSO

• Human Gene Id：
• 6652

• Human Swiss Prot No：
• Q00796

• Mouse Gene Id：
• 20322

• Mouse Swiss Prot No：
• Q64442

• Rat Gene Id：
• 24788

• Rat Swiss Prot No：
• P27867

• 免疫原：
• Synthesized peptide derived from human DHSO

• 特异性：
• This antibody detects endogenous levels of DHSO at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000 IP 1:200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 39kD

• 背景：
• Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010],

• 功能：
• catalytic activity:L-iditol + NAD(+) = L-sorbose + NADH.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family.,subunit:Homotetramer.,

• 细胞定位：
• Mitochondrion membrane ; Peripheral membrane protein . Cell projection, cilium, flagellum . Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. .

• 组织表达：
• Expressed in liver (PubMed:3365415). Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).

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