• 靶点：
• p40/p63

• 简介：
• >>MicroRNAs in cancer

• 基因名称：
• TP63 KET P63 P73H P73L TP73L

• 蛋白名称：
• p40

• Human Gene Id：
• 3662

• Human Swiss Prot No：
• Q9H3D4

• 免疫原：
• Synthesized peptide derived from human p40

• 特异性：
• This antibody detects endogenous levels of p40 at Human

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-1:200. IF 1:50-200, ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Tumor protein 63 (p63;Chronic ulcerative stomatitis protein;CUSP;Keratinocyte transcription factor KET;Transformation-related protein 63;TP63;Tumor protein p73-like;p73L;p40;p51)

• 功能：
• cofactor:Binds 1 zinc ion per subunit.,disease:Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers.,disease:Defects in TP63 are a cause of ectodermal dysplasia Rapp-Hodgkin type (EDRH) [MIM:129400]; also called Rapp-Hodgkin syndrome or anhidrotic ectodermal dysplasia with cleft lip/palate. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDRH is characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and

• 细胞定位：
• Nucleus .

• 组织表达：
• Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.

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