S100A6 (ABT179R) rabbit mAb
- 货号：YM7275
- 应用：IHC; ELISA
- 种属：Human;
- 免疫原：
- Synthesized peptide derived from human S100A6 AA range:50-90
- 特异性：
- This antibody detects endogenous levels of S100A6
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Monoclonal, Rabbit IgG1, Kappa
- 稀释：
- IHC 1:100-500, ELISA 1:5000-20000
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Protein S100-A6;Calcyclin;Growth factor-inducible protein 2A9;MLN 4;Prolactin receptor-associated protein;PRA;S100 calcium-binding protein A6
- 背景：
- S100 calcium binding protein A6(S100A6) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008],
- 功能：
- induction:Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.,miscellaneous:This protein co-purified with the prolactin receptor.,PTM:The N-terminus is blocked.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer, antiparallel. Interacts with SUGT1.,
- 细胞定位：
- Nuclear, Cytoplasmic
- 组织表达：
- Brain,Fibroblast,Placenta,Platelet,
- Immunohistochemical analysis of paraffin-embedded human Pancreatic carcinoma. 1, Antibody was incubated at 4° overnight. 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
- Immunohistochemical analysis of paraffin-embedded human Papillary thyroid carcinoma. 1, Antibody was incubated at 4° overnight. 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
