Collagen Type IV (ABT193R) rabbit mAb

  • 货号：YM7090
  • 应用：IHC;WB; ELISA
  • 种属：Human; (predicted: Mouse)
    • 靶点：
    • Collagen IV
    • 简介：
    • >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Protein digestion and absorption;>>Amoebiasis;>>Human papillomavirus infection;>>Pathways in cancer;>>Small cell lung cancer
    • 基因名称：
    • COL4A1
    • 蛋白名称：
    • Collagen Type IV
    • Human Gene Id：
    • 1282
    • Human Swiss Prot No：
    • P02462
    • 免疫原：
    • Synthesized peptide derived from human Collagen Type IV AA range:1600-1669
    • 特异性：
    • This antibody detects endogenous levels of Collagen IV
    • 组成：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • 来源：
    • Monoclonal, Rabbit IgG1, Kappa
    • 稀释：
    • IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
    • 纯化工艺：
    • Recombinant Expression and Affinity purified
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Arresten;BSVD;CO4A1_HUMAN;COL4A1;COL4A1 NC1 domain;COL4A2;COL4A3;COL4A4;COL4A5;collagen alpha-1(IV) chain;Collagen IV Alpha 1 Polypeptide;Collagen IV Alpha 2 Polypeptide;Collagen Of Basement Membrane Alpha 1 Chain;Collagen Of Basement Membrane Alpha 2 Chain;Collagen Type IV Alpha 1;collagen type IV alpha 1 chain;Collagen Type IV Alpha 2;Collagen Type IV Alpha 3;Collagen Type IV Alpha 4;Collagen Type IV Alpha 5;RatOR
    • 分子量：
    • 161kD
    • 背景：
    • This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
    • 功能：
    • disease:Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex bas
    • 细胞定位：
    • Cytoplasmic
    • 组织表达：
    • Highly expressed in placenta.

    相关报价

    • 货号：
    • YM7090
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-05-19
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