CD14 (ABT194R) rabbit mAb
- 货号：YM7032
- 应用：IHC; ELISA
- 种属：Human;
- 简介：
- >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Phagosome;>>Toll-like receptor signaling pathway;>>Hematopoietic cell lineage;>>Alcoholic liver disease;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Amoebiasis;>>Tuberculosis;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Lipid and atherosclerosis
- 免疫原：
- Synthesized peptide derived from human CD14 AA range:1-100
- 特异性：
- This antibody detects endogenous levels of CD14
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Monoclonal, Rabbit IgG1, Kappa
- 稀释：
- IHC 1:100-500, ELISA 1:5000-20000
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CD 14;CD_antigen=CD14;CD14;CD14 antigen;CD14 molecule;CD14_HUMAN;LPS-R;Mo2;Monocyte differentiation antigen CD14;Monocyte differentiation antigen CD14 urinary form;Monocyte differentiation antigen CD14, membrane-bound form;Myeloid cell specific leucine rich glycoprotein;Myeloid cell-specific leucine-rich glycoprotein
- 背景：
- The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010],
- 功能：
- function:Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.,
- 细胞定位：
- Membranous, Cytoplasmic
- 组织表达：
- Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
