B-Cell-Specific Activator Protein(PAX-5) (ABT109R) rabbit mAb

  • 货号：YM7016
  • 应用：WB; IHC; ELISA
  • 种属：Human; (predicted: Mouse)
    • 靶点：
    • MEK-4
    • 基因名称：
    • PAX5
    • 蛋白名称：
    • PAX-5
    • Human Gene Id：
    • 5079
    • Human Swiss Prot No：
    • Q02548
    • Mouse Swiss Prot No：
    • Q02650
    • 免疫原：
    • Synthesized peptide derived from human PAX-5 AA range:150-250
    • 特异性：
    • This antibody detects endogenous levels of MEK-4
    • 组成：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • 来源：
    • Monoclonal, Rabbit IgG1, Kappa
    • 稀释：
    • IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
    • 纯化工艺：
    • Recombinant Expression and Affinity purified
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)
    • 分子量：
    • 42kD
    • 背景：
    • The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
    • 功能：
    • developmental stage:Expressed at early B-cell differentiation, in the developing CNS and in adult testis.,disease:A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.,function:May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.,PTM:O-glycosylated.,similarity:Contains 1 paired domain.,subunit:Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4.,
    • 细胞定位：
    • Nucleus .

    相关报价

    • 货号：
    • YM7016
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-06-18
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