Integrin β3 (PTR2555) Mouse mAb

    • 货号:YM4695
    • 应用:WB;ELISA
    • 种属:Human (predicted: Mouse; Rat)
      • 靶点:
      • Integrin β3
      • 简介:
      • >>Rap1 signaling pathway;>>Phagosome;>>PI3K-Akt signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>ECM-receptor interaction;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Hematopoietic cell lineage;>>Regulation of actin cytoskeleton;>>Thyroid hormone signaling pathway;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Herpes simplex virus 1 infection;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy;>>Fluid shear stress and atherosclerosis
      • 基因名称:
      • ITGB3 GP3A
      • 蛋白名称:
      • Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
      • Human Gene Id:
      • 3690
      • Human Swiss Prot No:
      • P05106
      • Mouse Swiss Prot No:
      • O54890
      • 免疫原:
      • Synthesized peptide derived from human Integrin β3 AA range: 700-788
      • 特异性:
      • This antibody detects endogenous levels of Integrin β3 at Human, Mouse,Rat
      • 组成:
      • PBS, pH7.4, 50% glycerol, 0.03%Proclin 300
      • 来源:
      • Mouse,monoclonal:IgG1,Lambda
      • 稀释:
      • WB 1:500-2000,ELISA 1:5000-20000
      • 纯化工艺:
      • Protein G
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
      • 实测条带:
      • 87kDa
      • 背景:
      • integrin subunit beta 3(ITGB3) Homo sapiens The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008],
      • 功能:
      • disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.,function:Int
      • 细胞定位:
      • Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane . Cell junction, focal adhesion . Cell junction, synapse, postsynaptic cell membrane ; Single-pass type I membrane protein . Cell junction, synapse .
      • 组织表达:
      • Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
      • 产品图片
      • Whole cell lysates of A549 were separated by 10% SDS-PAGE, and the membrane was blotted with anti-Integrin β3(PTR2555) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: A549 Predicted band size: 87kDa Observed band size: 72kDa