• 靶点：
• AFP

• 简介：
• >>Hippo signaling pathway

• 基因名称：
• AFP

• 蛋白名称：
• Alpha-1-Fetoprotein(AFP)

• Human Gene Id：
• 174

• Human Swiss Prot No：
• P02771

• 免疫原：
• Synthesized peptide derived from human Alpha-1-Fetoprotein(AFP) AA range: 350-450

• 特异性：
• This antibody detects endogenous levels of human Alpha-1-Fetoprotein(AFP)

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal,Mouse IgG1, Kappa

• 稀释：
• WB 1:500-2000,IHC 1:100-300,ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin)

• 分子量：
• 69kD

• 背景：
• This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008],

• 功能：
• developmental stage:Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.,function:Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.,online information:Alpha-fetoprotein entry,PTM:Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.,PTM:Sulfated.,similarity:Belongs to the ALB/AFP/VDB family.,similarity:Contains 3 albumin domains.,subunit:Dimeric and trimeric forms have been found in addition to the monomeric form.,tissue

• 细胞定位：
• Secreted.

• 组织表达：
• Plasma. Synthesized by the fetal liver and yolk sac.

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