• 靶点：
• GADD45α

• 简介：
• >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>FoxO signaling pathway;>>Cell cycle;>>p53 signaling pathway;>>Apoptosis;>>Cellular senescence;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Colorectal cancer;>>Pancreatic cancer;>>Endometrial cancer;>>Glioma;>>Thyroid cancer;>>Basal cell carcinoma;>>Melanoma;>>Chronic myeloid leukemia;>>Small cell lung cancer;>>Non-small cell lung cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer

• 基因名称：
• gadd45a

• Human Gene Id：
• 1647

• Human Swiss Prot No：
• P24522

• Mouse Swiss Prot No：
• P48316

• 免疫原：
• Purified recombinant human GADD45 α protein expressed in E.coli

• 特异性：
• Transfected Only.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:1000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DDIT 1;DDIT-1;DDIT1;DNA damage inducible transcript 1;DNA damage-inducible transcript 1 protein;GA45A_HUMAN;GADD45;GADD45A;Growth arrest and DNA damage inducible 45 alpha;Growth arrest and DNA damage inducible alpha;Growth arrest and DNA damage-inducible protein GADD45 alpha.

• 实测条带：
• 22kD

• 背景：
• This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010],

• 功能：
• disease:Induction of GADD45 in ataxia telangiectasia cells is abnormal.,function:Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.,induction:By UV radiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC.,similarity:Belongs to the GADD45 family.,subunit:Interacts with GADD45GIP1.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Bronchial epithelial cells treated with 20 uM arsenic for 4

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