GDF-8 Monoclonal Antibody
- 货号：YM0303
- 应用：WB;ELISA
- 种属：Human
- 简介：
- >>Cytokine-cytokine receptor interaction
- 蛋白名称：
- Growth/differentiation factor 8
- 免疫原：
- Purified recombinant fragment of GDF-8 expressed in E. Coli.
- 特异性：
- GDF-8 Monoclonal Antibody detects endogenous levels of GDF-8 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- MSTN;GDF8;Growth/differentiation factor 8;GDF-8;Myostatin
- 背景：
- myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],
- 功能：
- function:Acts specifically as a negative regulator of skeletal muscle growth.,online information:Myostatin entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.,
- 组织表达：
- Colon,Muscle,Pericardium,Skeletal muscle,
- Western Blot analysis using GDF-8 Monoclonal Antibody against truncated GDF-8-His recombinant protein (1).
