- 靶点：
- BDH1
- 简介：
- >>Butanoate metabolism;>>Metabolic pathways
- 基因名称：
- BDH1
- 蛋白名称：
- D-beta-hydroxybutyrate dehydrogenase, mitochondrial
- Human Gene Id：
- 622
- Human Swiss Prot No：
- Q02338
- Mouse Gene Id：
- 71911
- Mouse Swiss Prot No：
- Q80XN0
- 免疫原：
- Purified recombinant fragment of human BDH1 expressed in E. Coli.
- 特异性：
- BDH1 Monoclonal Antibody detects endogenous levels of BDH1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Monoclonal, Mouse
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- BDH1;BDH;D-beta-hydroxybutyrate dehydrogenase; mitochondrial;BDH;3-hydroxybutyrate dehydrogenase
- 分子量：
- 38kD
- 背景：
- This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
- 功能：
- catalytic activity:(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.,enzyme regulation:Requires phosphatidylcholine as an allosteric activator for enzymatic activity.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Homotetramer.,
- 细胞定位：
- Mitochondrion inner membrane . Mitochondrion matrix .
- 组织表达：
- Heart,Lung,Ovary,
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- Antibody-FAQs
- 产品图片
- Western Blot analysis using BDH1 Monoclonal Antibody against HepG2 (1) and NIH/3T3 (2) cell lysate.
- Immunohistochemistry analysis of paraffin-embedded human liver cancer (left) and colorectal cancer tissues (right) with DAB staining using BDH1 Monoclonal Antibody.
