• 基因名称：
• THBS1

• 蛋白名称：
• Thrombospondin-1

• Human Gene Id：
• 7057

• Human Swiss Prot No：
• P07996

• Mouse Swiss Prot No：
• P35441

• 特异性：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• 储存：
• 2-8°C/6 months

• 其他名称：
• THBS1;TSP;TSP1;Thrombospondin-1

• 检测方法：
• Colorimetric

• 背景：
• function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 TSP type-1 domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homotrimer; disulfide-linked.,

• 功能：
• MAPKKK cascade, activation of MAPK activity, angiogenesis, blood vessel development, response to hypoxia,regulation of cytokine production, negative regulation of cytokine production, positive regulation of cytokine production, regulation of endothelial cell proliferation, negative regulation of endothelial cell proliferation, vasculature development, regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, sprouting angiogenesis,chronic inflammatory response, regulation of antigen processing and presentation, negative regulation of antigen processing and presentation, regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, regulation of dendritic cell antigen processing and presentation, negative regula

• 细胞定位：
• Secreted . Cell surface . Secreted, extracellular space, extracellular matrix . Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). .

Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction. BMC Cardiovascular Disorders Bmc Cardiovasc Disor. 2021 Dec;21(1):1-7 ELISA Human Blood
货号：KE1254

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