BOB.1 (ABT-BOB1) mouse mAb
- 货号：YM6111
- 应用：IHC;ELISA
- 种属：Human;Mouse;
- 蛋白名称：
- POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
- 免疫原：
- Synthesized peptide derived from human BOB.1 AA range: 150-256
- 特异性：
- The antibody can specifically recognize human BOB.1 protein.
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Mouse, Monoclonal/IgG2a, kappa
- 稀释：
- IHC 1:50-200. ELISA 1:500-5000
- 纯化工艺：
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景：
- disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,
- 功能：
- disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,
- 细胞定位：
- Nuclear, Cytoplasmic
- 组织表达：
- B-cell specific (PubMed:7779176, PubMed:7859290). Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine (PubMed:7779176, PubMed:7859290).
- Human diffuse large B-cell lymphoma tissue was stained with anti-BOB.1(ABT-BOB1) antibody.
- Human follicular lymphoma tissue was stained with anti-BOB.1(ABT-BOB1) antibody.
- Human tonsil tissue was stained with anti-BOB.1(ABT-BOB1) antibody.
- Human tonsil tissue was stained with anti-BOB.1(ABT-BOB1) antibody.
