Catalog: YM4539
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
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Main Information
Target
G3BP1
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
WB, IF, ELISA
MW
52kD (Calculated)
68kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of G3BP1 protein.
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
52kD
MW(Observed)
68kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PTR1324
Isotype
IgG2b,Kappa
Related Products
Primary Antibodies
G3BP1 Rabbit pAb
YT1808
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Primary Antibodies
G3BP1 (Phospho Ser232) Rabbit pAb
YP0117
More→
ELISA Kits
Total G3BP1 Cell-Based Colorimetric ELISA Kit
KA3111C
More→
ELISA Kits
G3BP1 (Phospho Ser232) Cell-Based Colorimetric ELISA Kit
KA1086C
More→
Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein. AA range: 200-300
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Specificity:
This antibody detects endogenous levels of G3BP1 protein.
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Gene Name:
G3BP1 G3BP
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Protein Name:
Ras GTPase-activating protein-binding protein 1 (G3BP-1) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
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Other Name:
Ras GTPase-activating protein-binding protein 1 ;
G3BP-1 ;
EC 3.6.4.13 ;
ATP-dependent DNA helicase VIII ;
hDH VIII ;
GAP SH3 domain-binding protein 1 ;
G3BP-1 ;
EC 3.6.4.13 ;
ATP-dependent DNA helicase VIII ;
hDH VIII ;
GAP SH3 domain-binding protein 1 ;
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Background:
G3BP stress granule assembly factor 1(G3BP1) Homo sapiens This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],
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Function:
ATP- and magnesium-dependent helicase that plays an essential role in innate immunity . Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA . In addition, plays an essential role in stress granule formation . Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends . Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency . Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA . Phosphorylation-dependent sequence-specific endoribonuclease in vitro . Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR .
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Tissue Expression:
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM4539
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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