Cytosolic DNA-sensing pathway
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
Product List
- POLR3A Rabbit pAbHuman,Mouse,MonkeyWB,IHC,IF,ELISA
- POLR3B Rabbit pAbHuman,Mouse,RatWB,IHC,IF,ELISA
- POLR3C Rabbit pAbHuman,Rat,Mouse,WB,ELISA,IHC
- POLR3D Rabbit pAbHuman,MouseWB,ELISA,IHC
- POLR3E Rabbit pAbHuman,MouseWB,IHC,IF,ELISA
- RPA40 Rabbit pAbHuman,MouseWB,ELISA
- RPC10 Rabbit pAbHuman,MouseWB,ELISA
- RPAC2 Rabbit pAbHuman,Rat,Mouse,WB,ELISA
- POLR3H Rabbit pAbHuman,Mouse,RatWB,IHC,IF,ELISA
- POLR3G Rabbit pAbHuman,Mouse,RatWB,IHC,IF,ELISA
Catalog
Product
Reactivity
Applications
- 1
- 2
- 3
- 4
- 33
PRODUCTS
CUSTOMIZED
ABOUT US
