Endogenous

IL1R1

Interleukin-1 receptor type 1

IL1R1 ;
IL1R ;
IL1RA ;
IL1RT1 ;
Interleukin-1 receptor type 1 ;
IL-1R-1 ;
IL-1RT-1 ;
IL-1RT1 ;
CD121 antigen-like family member A ;
Interleukin-1 receptor alpha ;
IL-1R-alpha ;
Interleukin-1 receptor type I ;
p80 ;
CD121a

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013],

Function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP.,

Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .

>>MAPK signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>NF-kappa B signaling pathway ;
>>Osteoclast differentiation ;
>>Hematopoietic cell lineage ;
>>Th17 cell differentiation ;
>>Inflammatory mediator regulation of TRP channels ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Amoebiasis ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Fluid shear stress and atherosclerosis