Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.
Product List
Catalog
Product
Reactivity
Applications
-
Lck (PT0416R) PT® Rabbit mAb
Human,Mouse,Rat,
WB,IHC,IF,IP,ELISA
-
Lck Rabbit pAb
Human,Mouse,Rat
WB,IHC,IF,ELISA
-
Lck (Phospho Tyr192) Rabbit pAb
Human,Mouse,Rat
WB,ELISA
-
Lck (Phospho Ser540) Rabbit pAb
Human,Mouse,Rat
WB,ELISA
-
Lck (Phospho Tyr393) Rabbit pAb
Human,Mouse,Rat
WB,IF,ELISA
-
Lck (Phospho Tyr505) Rabbit pAb
Human,Mouse,Rat
WB,IHC,IF,ELISA
-
Lck Mouse mAb
Human
WB,ELISA
-
LCK Mouse mAb
Human
WB
-
Lck (Phospho Tyr505) Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA
-
Lck (Phospho Tyr192) Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA