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NF-kappa B signaling pathway
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.

3553 (IL1B)7124 (TNF)1896 (EDA)1896 (EDA)3929 (LBP)23643 (LY96)959 (CD40LG)8600 (TNFSF11)4049 (LTA)4050 (LTB)8740 (TNFSF14)10673 (TNFSF13B)1896 (EDA)102723407 (IGH)3554 (IL1R1)7132 (TNFRSF1A)10913 (EDAR)60401 (EDA2R)929 (CD14)7099 (TLR4)958 (CD40)8792 (TNFRSF11A)4055 (LTBR)115650 (TNFRSF13C)60401 (EDA2R)3932 (LCK)7535 (ZAP70)27040 (LAT)5335 (PLCG1)6850 (SYK)4067 (LYN)29760 (BLNK)695 (BTK)5336 (PLCG2)4615 (MYD88)3654 (IRAK1), 51135 (IRAK4)7189 (TRAF6)8737 (RIPK1)8717 (TRADD)7186 (TRAF2), 7188 (TRAF5)329 (BIRC2), 330 (BIRC3)128178 (EDARADD)7189 (TRAF6)1540 (CYLD)7187 (TRAF3)7189 (TRAF6)23586 (RIGI)7706 (TRIM25)7186 (TRAF2), 7189 (TRAF6)114609 (TIRAP)4615 (MYD88)3654 (IRAK1), 51135 (IRAK4)7189 (TRAF6)353376 (TICAM2)148022 (TICAM1)8737 (RIPK1)7189 (TRAF6)7189 (TRAF6)7187 (TRAF3)7186 (TRAF2)329 (BIRC2), 330 (BIRC3)7189 (TRAF6)7186 (TRAF2)7186 (TRAF2)7188 (TRAF5)9020 (MAP3K14)7186 (TRAF2)7187 (TRAF3)7186 (TRAF2)7187 (TRAF3)7187 (TRAF3)329 (BIRC2), 330 (BIRC3)7189 (TRAF6)5588 (PRKCQ)5579 (PRKCB)29775 (CARD10), 79092 (CARD14), 84433 (CARD11)8915 (BCL10)10892 (MALT1)23085 (ERC1)8517 (IKBKG)1147 (CHUK)8517 (IKBKG)3551 (IKBKB)6885 (MAP3K7)10454 (TAB1), 23118 (TAB2), 257397 (TAB3)4792 (NFKBIA)10848 (PPP1R13L)4790 (NFKB1)5970 (RELA)695 (BTK)4792 (NFKBIA)4790 (NFKB1)5970 (RELA)1457 (CSNK2A1), 1459 (CSNK2A2), 1460 (CSNK2B), 283106 (CSNK2A3)4792 (NFKBIA)4790 (NFKB1)5970 (RELA)9020 (MAP3K14)1147 (CHUK)4791 (NFKB2)5971 (RELB)4791 (NFKB2)472 (ATM)8517 (IKBKG)142 (PARP1)51588 (PIAS4)7329 (UBE2I)8517 (IKBKG)55367 (PIDD1)8737 (RIPK1)329 (BIRC2), 330 (BIRC3)8837 (CFLAR)331 (XIAP)598 (BCL2L1)596 (BCL2)10912 (GADD45G), 1647 (GADD45A), 4616 (GADD45B)7185 (TRAF1), 7186 (TRAF2)597 (BCL2A1)4791 (NFKB2)3576 (CXCL8)3553 (IL1B)7124 (TNF)7128 (TNFAIP3)4792 (NFKBIA)5743 (PTGS2)388372 (CCL4L1), 6351 (CCL4), 9560 (CCL4L2)2919 (CXCL1), 2920 (CXCL2), 2921 (CXCL3)7412 (VCAM1)5328 (PLAU)598 (BCL2L1)598 (BCL2L1)597 (BCL2A1)6357 (CCL13)6363 (CCL19)6366 (CCL21)6387 (CXCL12)10673 (TNFSF13B)3383 (ICAM1)


Product List
    Catalog
    Product
    Reactivity
    Applications
  • Lck (PT0416R) PT® Rabbit mAb
    Human,Mouse,Rat,
    WB,IHC,IF,IP,ELISA
  • Lck Rabbit pAb
    Human,Mouse,Rat
    WB,IHC,IF,ELISA
  • Lck (Phospho Tyr192) Rabbit pAb
    Human,Mouse,Rat
    WB,ELISA
  • Lck (Phospho Ser540) Rabbit pAb
    Human,Mouse,Rat
    WB,ELISA
  • Lck (Phospho Tyr393) Rabbit pAb
    Human,Mouse,Rat
    WB,IF,ELISA
  • Lck (Phospho Tyr505) Rabbit pAb
    Human,Mouse,Rat
    WB,IHC,IF,ELISA
  • Lck Mouse mAb
    Human
    WB,ELISA
  • LCK Mouse mAb
    Human
    WB
  • Lck (Phospho Tyr505) Cell-Based Colorimetric ELISA Kit
    Human,Mouse,Rat
    ELISA
  • Lck (Phospho Tyr192) Cell-Based Colorimetric ELISA Kit
    Human,Mouse,Rat
    ELISA
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