CASP9

CASP9 ;
MCH6 ;
Caspase-9 ;
CASP-9 ;
Apoptotic protease Mch-6 ;
Apoptotic protease-activating factor 3 ;
APAF-3 ;
ICE-like apoptotic protease 6 ;
ICE-LAP6 ;
[Cleaved into: Caspase-9 subunit p35 ;
Caspase-9 subunit p10]

catalytic activity:Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa. ,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . ,function:Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. ,online information:Caspase-9 entry ,PTM:Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events. ,similarity:Belongs to the peptidase C14A family. ,similarity:Contains 1 CARD domain. ,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers , each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2 , BIRC4 , BIRC5 and BIRC7. ,tissue specificity:Ubiquitous , with highest expression in the heart , moderate expression in liver , skeletal muscle , and pancreas. Low levels in all other tissues. ,

proteolysis , apoptosis , activation of caspase activity , response to DNA damage stimulus , cell death , activation of caspase activity by cytochrome c , response to radiation , response to UV , response to light stimulus , response to abiotic stimulus , regulation of cell death , positive regulation of cell death , positive regulation of peptidase activity ,programmed cell death , death , cellular response to stress , regulation of apoptosis , positive regulation of apoptosis ,regulation of programmed cell death , positive regulation of programmed cell death , positive regulation of catalytic activity , positive regulation of caspase activity , regulation of caspase activity , regulation of neuron apoptosis , positive regulation of neuron apoptosis , positive regulation of molecular function , regulation of hydrolase activity , positive regulation of hydrolase activity , regulation of peptidase activity , regulation of endopeptidase activity ,