CCNE1

G1/S-specific cyclin-E1

function:Essential for the control of the cell cycle at the G1/S (start) transition. ,PTM:Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the cyclin family. Cyclin E subfamily. ,subunit:Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2 , CABLES1 and CCNA1 (By similarity) . Part of a complex consisting of UHRF2 , CDK2 and CCNE1. ,tissue specificity:Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. ,

G1/S transition of mitotic cell cycle , mitotic cell cycle , ovarian follicle development , antral ovarian follicle growth , liver development , reproductive developmental process , regulation of transcription , DNA-dependent , cell cycle , intracellular signaling cascade , sex differentiation , response to nutrient , gonad development , female gonad development ,response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process ,response to extracellular stimulus , response to organic substance , response to organic nitrogen , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , response to organic cyclic substance , response to purine , cell cycle process , cell cycle phase ,ovulation cycle process , steroid hormone receptor signaling pathway , androgen receptor signaling pathway ,intracellular receptor-mediated signaling pathway , regeneration , organ regeneration , positive regulation of cellular biosynthetic process , response to nutrient levels , cellular response to extracellular stimulus , cellular response to nutrient levels , cellular response to nutrient , response to corticosteroid stimulus , response to estradiol stimulus ,multicellular organism reproduction , response to progesterone stimulus , response to vitamin E , response to vitamin ,response to cytokine stimulus , growth , response to drug , ovulation cycle , response to estrogen stimulus ,development of primary sexual characteristics , regulation of transcription , response to ethanol , positive regulation of cell differentiation , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , development of primary female sexual characteristics , female sex differentiation , rhythmic process , response to steroid hormone stimulus ,developmental growth , reproductive structure development , reproductive process in a multicellular organism , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , cell division , interphase , interphase of mitotic cell cycle , response to glucocorticoid stimulus , response to mineralocorticoid stimulus , response to corticosterone stimulus ,response to methylmercury ,

Nucleus .