Catalog: YP1317
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
DR6 Phospho Ser562
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
72kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat DR6 (phospho-Ser562)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
72kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human DR6 (Ser562)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat DR6 (phospho-Ser562)
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Gene Name:
TNFRSF21 DR6 UNQ437/PRO868
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Protein Name:
DR6 (Ser562)
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Other Name:
Tumor necrosis factor receptor superfamily member 21 ;
Death receptor 6 ;
CD antigen CD358 ;
Death receptor 6 ;
CD antigen CD358 ;
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Background:
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013],
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Function:
Caution:It is uncertain whether Met-1 or Met-25 is the initiator.,Function:May activate NF-kappa-B and JNK and promote apoptosis.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Associates with TRADD.,tissue specificity:Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
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Research Areas:
>>Cytokine-cytokine receptor interaction
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1317
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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