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Vascular smooth muscle contraction
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement. The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Product List
    Catalog
    Product
    Reactivity
    Applications
  • AR-α1A Rabbit pAb
    Human,Mouse,Rat
    WB,IF,ELISA
  • AR-α1A Rabbit pAb
    Human,Rat,Mouse,
    WB,IHC,IF,ELISA
  • AR-α1B Rabbit pAb
    Human,Mouse,Rat
    WB,IF,ELISA
  • AR-α1D Rabbit pAb
    Human,Rat,Mouse,
    IHC,IF,ELISA
  • AGT Mouse mAb
    Human
    WB,ELISA
  • Rat ANG II(Angiotensin II) ELISA Kit
    Rat
    ELISA
  • Rat AGT(Angiotensinogen) ELISA Kit
    Rat
    ELISA
  • Rat ANG I(Angiotensin I) ELISA Kit
    Rat
    ELISA
  • Human Ang-II(Angiotensin II) ELISA Kit
    Human
    ELISA
  • Human Ang-I(Angiotensin I) ELISA Kit
    Human
    ELISA
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