The specific immunogen used to produce this antibody is proprietary information.

Endogenous

SMAD5

Mothers against decapentaplegic homolog 5

SMAD5 ;
MADH5 ;
Mothers against decapentaplegic homolog 5 ;
MAD homolog 5 ;
Mothers against DPP homolog 5 ;
JV5-1 ;
SMAD family member 5 ;
SMAD 5 ;
Smad5 ;
hSmad5

The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

Function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2.,tissue specificity:Ubiquitous.,

Cytoplasm,Nucleus

>>Cell cycle ;
>>Endocytosis ;
>>Cellular senescence ;
>>TGF-beta signaling pathway ;
>>Apelin signaling pathway ;
>>Hippo signaling pathway ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Th17 cell differentiation ;
>>Relaxin signaling pathway ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Chagas disease ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Colorectal cancer ;
>>Pancreatic cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer ;
>>Inflammatory bowel disease ;
>>Diabetic cardiomyopathy