TMEM173 (Phospho Ser365) (PT1380R) PT™ Rabbit mAb
-YM9222
Catalog: YM9222
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
STING/TMEM173 Phospho Ser365
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
42kD (Calculated)
37kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-1:5000; ELISA 1:5000-1:20000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
TMEM173 (Phospho Ser365) Antibody detects endogenous levels of Mouse TMEM173 protein only when phosphorylated at S365.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LIsGM
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
42kD
MW(Observed)
37kD
Modification
phosphate
Clonality
Monoclonal
Clone Number
PT1380R
Isotype
IgG, Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
TMEM173 (Phospho Ser365) Antibody detects endogenous levels of Mouse TMEM173 protein only when phosphorylated at S365.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LIsGM
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Gene Name:
TMEM173 ERIS MITA STING
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Protein Name:
Transmembrane protein 173
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Other Name:
TMEM173 ;
ERIS ;
MITA ;
STING ;
Transmembrane protein 173 ;
Endoplasmic reticulum interferon stimulator ;
ERIS ;
Mediator of IRF3 activation ;
hMITA ;
Stimulator of interferon genes protein ;
hSTING
ERIS ;
MITA ;
STING ;
Transmembrane protein 173 ;
Endoplasmic reticulum interferon stimulator ;
ERIS ;
Mediator of IRF3 activation ;
hMITA ;
Stimulator of interferon genes protein ;
hSTING
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Background:
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq , Sep 2014] ,
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Function:
Function:Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function , the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) . Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. ,PTM:Phosphorylated on tyrosine residues upon MHC-II aggregation. ,subunit:Associates with the MHC-II complex (By similarity) . Interacts with DDX58/RIG-I , MAVS/VISA and SSR2. ,tissue specificity:Ubiquitously expressed. ,
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Cellular Localization:
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cytoplasm , perinuclear region . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle , autophagosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . In response to double-stranded DNA stimulation , translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post-Golgi vesicles , where the kinase TBK1 is recruited (PubMed:19433799 , PubMed:30842659 , PubMed:30842653 , PubMed:29694889) . Upon cGAMP-binding , translocates to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in a process that is dependent on COPII vesicles; STING1-containing ERGIC serves as a membrane source for LC3 lipidation , which is a key step in autophagosome biogenesis (PubMed:30842662) . .
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Tissue Expression:
Research Areas:
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>Shigellosis ;
>>Human cytomegalovirus infection ;
>>Herpes simplex virus 1 infection ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19
>>RIG-I-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>Shigellosis ;
>>Human cytomegalovirus infection ;
>>Herpes simplex virus 1 infection ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19
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Signaling Pathway
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Catalog: YM9222
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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