• 靶点：
• NH2L1

• 简介：
• >>Ribosome biogenesis in eukaryotes;>>Spliceosome

• 基因名称：
• NHP2L1

• 蛋白名称：
• NH2L1

• Human Gene Id：
• 4809

• Human Swiss Prot No：
• P55769

• Mouse Gene Id：
• 100862468

• Mouse Swiss Prot No：
• Q9D0T1

• Rat Gene Id：
• 100359574

• Rat Swiss Prot No：
• P55770

• 免疫原：
• Synthesized peptide derived from human NH2L1 AA range: 33-83

• 特异性：
• This antibody detects endogenous levels of NH2L1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 14kD

• 背景：
• Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• function:Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.,similarity:Belongs to the ribosomal protein L7Ae family.,subcellular location:Concentrated in the dense fibrillar component of the nucleolus.,subunit:Interacts with RAD17.,tissue specificity:Ubiquitous.,

• 细胞定位：
• Nucleus . Nucleus, nucleolus . Concentrated in the dense fibrillar component of the nucleolus. .

• 组织表达：
• Ubiquitous.

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