PAR1 (Cleaved-Ser42) Polyclonal Antibody
- 货号:YT6162
- 应用:WB;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>Rap1 signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>Complement and coagulation cascades;>>Platelet activation;>>Regulation of actin cytoskeleton;>>Pathogenic Escherichia coli infection;>>Pathways in cancer
- 蛋白名称:
- Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
- 免疫原:
- Synthesized peptide derived from human PAR1 (Cleaved-Ser42) Polyclonal
- 特异性:
- This antibody detects endogenous levels of PAR1 (Cleaved-Ser42).
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500-2000, ELISA 1:10000-20000
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
- 背景:
- Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
- 功能:
- function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,
- 细胞定位:
- Cell membrane; Multi-pass membrane protein.
- 组织表达:
- Platelets and vascular endothelial cells.
- Western blot analysis of MCF-7 lysate, antibody was diluted at 1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000