• 靶点：
• Thrombin R

• 简介：
• >>Rap1 signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>Complement and coagulation cascades;>>Platelet activation;>>Regulation of actin cytoskeleton;>>Pathogenic Escherichia coli infection;>>Pathways in cancer

• 基因名称：
• F2R

• 蛋白名称：
• Proteinase-activated receptor 1

• Human Gene Id：
• 2149

• Human Swiss Prot No：
• P25116

• Mouse Swiss Prot No：
• P30558

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PAR1. AA range:23-72

• 特异性：
• Cleaved-Thrombin R (S42) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin R protein resulting from cleavage adjacent to S42.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• F2R;CF2R;PAR1;TR;Proteinase-activated receptor 1;PAR-1;Coagulation factor II receptor;Thrombin receptor

• 实测条带：
• 46kD

• 背景：
• Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

• 功能：
• function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Platelets and vascular endothelial cells.

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