• 靶点：
• MAG

• 简介：
• >>Cell adhesion molecules

• 基因名称：
• MAG

• 蛋白名称：
• Myelin-associated glycoprotein

• Human Gene Id：
• 4099

• Human Swiss Prot No：
• P20916

• Mouse Gene Id：
• 17136

• Mouse Swiss Prot No：
• P20917

• Rat Gene Id：
• 29409

• Rat Swiss Prot No：
• P07722

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human MAG. AA range:501-550

• 特异性：
• MAG Polyclonal Antibody detects endogenous levels of MAG protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MAG;GMA;Myelin-associated glycoprotein;Siglec-4a

• 实测条带：
• 70kD

• 背景：
• The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010],

• 功能：
• function:Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid.,online information:Siglec-4,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to RTN4R.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein . Membrane raft .

• 组织表达：
• Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552).

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