• 靶点：
• TIMP1

• 简介：
• >>HIF-1 signaling pathway

• 基因名称：
• TIMP1

• 蛋白名称：
• Metalloproteinase inhibitor 1

• Human Gene Id：
• 7076

• Human Swiss Prot No：
• P01033

• Mouse Gene Id：
• 21857

• Mouse Swiss Prot No：
• P12032

• Rat Gene Id：
• 116510

• Rat Swiss Prot No：
• P30120

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TIMP1. AA range:61-110

• 特异性：
• TIMP-1 Polyclonal Antibody detects endogenous levels of TIMP-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IF 1:50-200 WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TIMP1;CLGI;TIMP;Metalloproteinase inhibitor 1;Erythroid-potentiating activity;EPA;Fibroblast collagenase inhibitor;Collagenase inhibitor;Tissue inhibitor of metalloproteinases 1;TIMP-1

• 实测条带：
• 24kD

• 背景：
• This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008],

• 功能：
• function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.,PTM:The activity of TIMP1 is dependent on the presence of disulfide bonds.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,

• 细胞定位：
• Secreted .

• 组织表达：
• Detected in rheumatoid synovial fluid (at protein level).

Kangfuxin Oral Liquid Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF-β1/Smad Pathway. Evidence-based Complementary and Alternative Medicine Evid-Based Compl Alt. 2019;2019:5124026 IHC Rat 1 : 200 Lung tissue
货号：YT4658

Recombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1. African Health Sciences Afr Health Sci. 2016 Jul;16(2):542-553 WB Rabbit wound area tissue
货号：YT4658

Early Continuous Passive Motion and Needle-Knife Therapy Alleviate Knee Motor Dysfunction Effects After Internal Fixation of TPFs. Li Jia IHC Rabbit 1:50 ligamentous tissue
货号：YT4658

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